
- MultiSpecies
- USES-WesternblottingandChIP
- WIDEAPPLICATION-HistoneH3fromyeasttomammals.
AbX™HistoneH3RabbitPolyclonalAntibodyforWesternblottingandChIP.
Chromosomalsurfacesareornamentedwithavarietyofposttranslationalmodificationsofhistones,whicharerequiredfortheregulationofmanyoftheDNA-templatedprocesses.HistoneH3isoneofthefivemainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongN-terminustail,H3isinvolvedwiththe‘beadsonastring’structureofthenucleosome.HistoneH3isthemostextensivelypost-translationallymodifiedofthefivehistones.Theterm“HistoneH3”aloneispurposelyambiguousinthatitdoesnotdistinguishbetweensequencevariantsormodificationstate.HistoneH3isanimportantproteinintheemergingfieldofepigenetics,whereitssequencevariantsandvariablemodificationstatesarethoughttoplayaroleintheregulationofgenes.Forexample,histonemethylationeitherontheirarginineand/orlysineresidues,yieldsamorediversearrayofcellularfunctions.