
- MostSensitive
- MultiSpecies
- USE-KidneyFunctionMeasuredin90MInutes
- SAMPLE-Urine,DriedBloodSpot(DBS)
- SAMPLES/KIT-41inDuplicate
- STABILITY-Stable4˚CLiquidReagents
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TheDetectX®RBPHighSensitivityImmunoassayKit(formerlynamedUrinaryRBPEIAKit)isdesignedtomeasureRBPlevelsinurineanddriedbloodspots.ThiskitusesanativehumanRBPmoleculeasastandard.StandardsordilutedsamplesareaddedtoacoatedmicrotiterplatealongwithaRBP-peroxidaseconjugateandthebindingreactioninitiatedbyadditionofaRBP-specificrabbitantibody.Aftera60-minuteincubation,theplateiswashedandTMBsubstratesolutionadded.After30minutestheintensityofthegeneratedsignalisreadat450nm.
Retinolbindingprotein(RBP)isfromafamilyofstructurallyrelatedproteinsthatbindsmallhydrophobicmoleculessuchasbilepigments,steroids,odorants,etc.RBPisa21kDahighlyconserved,single-chainglycoprotein,consistingof182aminoacidswith3disulfidebonds,thathasahydrophobicpocketwhichbindsretinol.RBPhasbeenshowntobeausefulMarkerforrenalfunctionasitistotallyfilteredbytheglomeruliandreabsorbedbyproximaltubules.ThishasmadeRBPatooltostudyrenalfunctioninheartorkidneytransplantrecipients,type1and2diabetics,andinpeopleexposedtouraniumfromminingoperations.MeasurementofRBPlevelshasalsobeenusefulindetectionandcharacterizationofdiseasesincludinghypertensionandcertaincancers,amongotherconditions.
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