- MostSensitive
 
- USE-KidneyInjuryMarker,Resultsin2Hours
 - SAMPLE-Serum,Plasma,UrineorTCM
 - SAMPLES/KIT-40inDuplicate
 - STABILITY-Stable4˚CLiquidReagents
 
ViewPublications
TheDetectX®CystatinCImmunoassayKitisdesignedtomeasureHumanCystatinClevelsinavarietyofBIOLOGicalmatrices.ThiskitusesamicrotiterplatecoatedwithamonoclonaltoCystatinCandanativehumanCystatinCmoleculestandard.SamplesandstandardsareaddedtotheplateandafteranhourincubationatRTtheplateiswashedandmonoclonalantibody-peroxidaseconjugateisadded.Aftera30-minuteincubationatRT,theplateiswashedandTMBsubstratesolutionaddedtoeachwell.Thecolorreactionisreadat450nm.
CystatinCisanon-glycosylatedproteinoflowmolecularweight(13kDa)inthecystatinsuperfamily.CystatinCisproducedataconstantrateinallnucleatedcells.CystatinCbelongstothecysteineproteinaseinhibitorgroupandisassociatedwithseveralpathologicalconditions.ImbalancebetweenCystatinCandcysteineproteinasesisassociatedwithdiseasessuchasinflammation,renalfailure,cancer,Alzheimer’sdisease,multiplesclerosisandhereditaryCystatinCamyloidangiopathy.CystatinCisremovedfrombloodplasmabyglomerularfiltrationinthekidneys.Itisreabsorbedbytheproximaltubularcellsanddegraded.ThereisalinearrelationshipbetweenthereciprocalCystatinCconcentrationinplasmaandtheglomerularfiltrationrate(GFR).CystatinCissuggestedtobeabettermarkerforGFRthanothermarkersasitsserumconcentrationisnotaffectedbyotherfactorssuchasage,genderandbodymass.ThereisassociationofCystatinClevelswiththeincidenceofmyocardialinfarctionandcoronarydeath,presentingariskfactorforsecondarycardiovascularevents.

DataReductionTemplatebyMyAssays

		