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- MostSensitive
- MultiSpecies
- USE-MeasureAChEActivityin20MinutesorKinetically
- SAMPLE-CSF,Serum,Plasma,RBCGhosts
- SAMPLES/KIT-90inDuplicate
- SENSITIVE-Measure<0.25mu/ml=""of=""ache="">
- STABILITY-AllReagentsStableat4°C
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TheDetectX®Acetylcholinesterase(AChE)ActivitykitisdesignedtoquantitativelymeasureAChEactivityinavarietyofsamples.AhumanAChEstandardisprovidedtogenerateastandardcurvefortheassay.Thekitutilizesaproprietarynon-fluorescentmolecule,ThioStar®,thatcovalentlybindstothethiolproductofthereactionbetweentheAChESubstrateandAChEinthestandardsorsamples,yieldingafluorescentproductreadat510nminafluorescentplatereaderwithexcitationat390nm.
Acetylcholinesterases(AChE)appearcriticaltobothdevelopmentandfunctionofthenervoussystem.TheuseofAChEinhibitorsastherapeuticagentsandpesticideshasspurreddetailedinvestigationsofcholinesterasessincetheiridentificationbyDale.Acetylcholine(ACh)isanessentialneurotransmitterinthecentralandperipheralnervoussystems.Inthebrainmultipleareasexistwherecholinergicneuronsareconcentrated.NicotinicandmuscarinicAChreceptorsarerecognizedasbindingandeffectorproteinstomediatechemicalneurotransmissionatneurons,ganglia,heartandsmoothmusclefibersandglands.ThistrADItionalviewofAChEactingsolelyasneurotransmitterhastoberevisedbasedonthefindingspublishedbothearlyandlateinthelastcentury,demonstratingthenon-neuronalcholinergicsystem.
DataReductionTemplatebyMyAssays